jhvdJHVDJHVD2053-2644A Cadaveric Based Morphometric Analysis of Sciatic nerve with clinical significanceAkula GangadharReddyVimal NoneModiDepartment of Anatomy, Index Medical College, Indore, Madhya Pradesh, IndiaBackground: The sciatic nerve is the largest nerve in the human body, as well as in many other animals. There are two reasons for this; one being that there are numerous neural fibres that gather to produce this nerve, and secondly, due to the extensive size of the gluteal region and lower limb, in other words, the regions innervated by this nerve. The sciatic nerve develops from the lumbo-sacral plexus, from the fourth lumbar to the third sacral (L4-L5 and S1-S3) spinal nerves. The nerve often has a maximum width of two centimetres (cm) or more, and can reach a diameter of over 0.5 cm, as it passes posterior and inferior to piriformis. The sciatic nerve is described as the nerve with the largest diameter in the body.  Materials and Methods: This is a Prospective, observational study and Conventional Routine dissection method. 800 Embalmed human adult cadavers lower limb specimens. Adult lower limb specimens were obtained from the embalmed cadavers allotted for routine dissection to the first year MBBS students at the Department of Anatomy, Index Medical college. Both right and left lower limbs were used from all 800 cadavers. Therefore, every right lower limb has a corresponding left lower limb. Specimens where damage to piriformis or the sciatic nerve observed was excluded. Results : In our study the SN exited inferior to the PM in 736 lower limbs (92%); between the fascicles of the PM and inferior to the PM in two lower limbs (6%); and in one thigh, between the fascicles of the PM and superior to the PM (2%). The anatomical variations that are always unilateral occurred more frequently in the left side (11%) compared to the right side (6%). Conclusion: The goal of this project was to identify the anatomical variations of the sciatic nerve divisions in relation to the piriformis muscle and provide awareness of additional sciatic nerve entrapments that are possible within the subgluteal space. While piriformis syndrome was once the “catch-all” diagnosis for posterior hip and buttock pain, there are many potential causes that need to be explored, including sciatic nerve entrapment within the subgluteal space.