Early detection of heart valve dysfunction is crucial for effective management and improved patient outcomes. Cardiac biomarkers have emerged as valuable tools in identifying and monitoring valve disease, offering insights into disease presence, severity, and progression. This article reviews the role of various cardiac biomarkers in the early detection of heart valve dysfunction, discussing their mechanisms, diagnostic performance, and clinical applications. By synthesizing recent research, we aim to highlight the potential of these biomarkers in enhancing early diagnosis and guiding treatment strategies.