Heart valve disease (VHD) presents with different prevalence rates and clinical outcomes based on gender, impacting diagnosis, treatment decisions, and prognosis. This article examines the gender-specific differences in the prevalence, clinical manifestations, and outcomes of various types of heart valve disease, including aortic stenosis, mitral regurgitation, and other valvular conditions. It also explores the implications for management strategies and future research directions to address these disparities.