Radiation therapy, commonly used in the treatment of various malignancies, has been associated with long-term cardiovascular complications, including heart valve dysfunction. This longitudinal study investigates the effects of radiation therapy on heart valve function over an extended period. We analyze changes in valve function, mechanisms of radiation-induced damage, and implications for patient management. The findings underscore the importance of monitoring heart valve health in patients with a history of radiation therapy and provide insights into potential preventive and therapeutic strategies.