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Research Article | Volume 28 Issue 1 (, 2023) | Pages 1 - 5
The Role of Extracellular Matrix Remodeling in Valve Disease Progression
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Under a Creative Commons license
Open Access
Received
Feb. 13, 2022
Revised
June 17, 2022
Accepted
Oct. 20, 2022
Published
Dec. 30, 2022
Abstract

Extracellular matrix (ECM) remodeling is a fundamental process in the pathogenesis of heart valve diseases. This review examines the role of ECM remodeling in valve disease progression, highlighting the molecular mechanisms, key regulatory factors, and clinical implications. We discuss how alterations in ECM composition and structure contribute to the development and progression of various heart valve diseases, including aortic stenosis, mitral regurgitation, and tricuspid valve disorders. The review also explores potential therapeutic strategies targeting ECM remodeling to mitigate valve disease progression.

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