Contents
Download PDF
238907 Views
12907 Downloads
Share this article
Research Article | Volume 26 Issue 4 (, 2017) | Pages 397 - 404
Long-Term Results of Aortic Root Surgery in Marfan Syndrome Patients: A Single-Center Experience
 ,
 ,
 ,
 ,
 ,
 ,
 ,
 ,
 ,
 ,
1
Cardiac Surgery Unit and Marfan Center, Tor Vergata University Policlinic, Rome, Italy. Electronic correspondence: nicolo_francy84@hotmail.it.
2
Department of Cardiovascular Disease, Tor Vergata University Policlinic, Rome, Italy.
3
Cardiac Surgery Unit and Marfan Center, Tor Vergata University Policlinic, Rome, Italy.
4
Cardiac Surgery Unit, Clinica Mediterranea, Naples, Italy.
Under a Creative Commons license
PMID : -29302938
Published
July 10, 2017
Abstract

Background and aim of the study: The study aim was to compare long-term results of Marfan syndrome (MFS) patients affected by aortic root disease undergoing aortic root replacement with the Bentall or David operation.

Methods: Since 1994, a total of 59 patients has been followed at the authors' Marfan Center, having undergone either a Bentall operation (Bentall group, n = 30) or a David operation (David group, n = 29).

Results: No operative mortality was recorded. After 20 years (mean follow up 97 ± 82 months; range 1 to 369 months) no prosthesis-related major bleeding or thromboembolic events had been observed; the 20-year survival was 94 ± 6% in the Bentall group, and 100% in the David group (p = 0.32). Freedom from reintervention for aortic valve dysfunction was 100% in the Bentall group, and 75 ± 13% in the David group (p = 0.04). This inter-group difference became relevant after the first eight-year period of follow-up, and was mainly associated with a particular familiar genetic phenotype involving three out of four reoperated patients. Freedom from all-cause death, myocardial infarction, stroke, prosthetic valve-related complications, and reintervention on any aortic segment was 69 ± 12% in the Bentall group, and 67 ± 14% in the David group (p = 0.33).

Conclusions: The Bentall and David operations are both associated with satisfactory long-term results in MFS patients. The low rate of valve prosthesis-related complications suggested that the Bentall operation would continue to be a standard surgical treatment. The reimplantation technique, adopted for less-dilated aortas, provides satisfactory freedom from reoperation. Careful attention should be paid to the reimplantation technique in patients affected by a serious familiar genetic phenotype.

 

 

 

How to cite: Nicolo, F., Romeo, F., Lio, A., Bovio, E., Scafuri, A., Bassano, C., Polisca, P., Pellegrino, A., Nardi, P., Chiariello, L., & Ruvolo, G. (2017). Long-Term Results of Aortic Root Surgery in Marfan Syndrome Patients: A Single-Center Experience. The Journal of heart valve disease26(4), 397–404.

 
Recommended Articles
Research Article
Mechanical aortic valve replacement: long-term outcomes in children
...
Download PDF
Research Article
Emerging Biomarkers for Early Detection of Heart Valve Disease
Download PDF
Research Article
Clinical Outcomes of Valve-in-Valve Procedures for Failed Bioprosthetic Valves
Download PDF
Research Article
Genetic Predisposition and Its Role in Congenital Heart Valve Malformations
Download PDF
Chat on WhatsApp
Copyright © The Journal Of Heart Valve Disease. All Rights Reserved.